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Woo Hoo!  So here it is, almost 10 months after I started this ReCode (Reverse Cognitive Decline) Clinical Trial.

Allow me to back up for a moment and share with you what got me concerned about my brain health in the first place. Back in 2019 and before, I noticed I was forgetting people, appointments, names, why I was holding the object in my hands, and so on.  True it’s common for that to happen occasionally but it was happening more and more frequently. I have a strong family history of Alzheimer’s disease and I was worried.

Through clinical study genetic testing, I learned that I carry the ApoE4 gene, that sucky one that makes me susceptible to Alzheimer’s disease. The good news from the book “End of Alzheimer’s”  written by Dr. Dale Bredesen from which this clinical trial is based, is that your genes are not your destiny.  I believe that is true really of any genetic predisposition you might have for whatever disease. The genetic gun may be loaded but you have the power and choice to avoid the triggers that will tip the balance that puts you over the edge.  Those are the secrets I learned in this trial. How not to pull the trigger.

Time to celebrate!

What are my key learnings from this clinical trial that might help you?  I’ve experienced improvements in cognition, weight loss, sleep, gum health, and overall energy.  When reading the recommendations given to me, keep in mind that many of the nutritional supplements and hormone choices were selected for my unique biochemistry so the type and dosage may not translate to you. Best to consult with your own wellness practitioner for customization.

My Cognition Improved
The Recode protocol which includes a combination of a Ketogenic diet, Intermittent Fasting, exercise, nutritional and hormonal supplementation, brain training, and mindfulness training has helped me to crawl out of the abyss of cognitive decline.

  • Cognitive function tests have all markedly improved since baseline testing in December of 2019 to the point of testing “out of the range” of cognitive decline to normal levels.  I was in the range of “cognitive decline” for my initial testing.

I lost considerable weight

  • I lost 15 pounds on this diet, with a noticeable improvement around my waistline. I’ve lost fat but not muscle as evidenced by the physical testing that I underwent at the beginning and end of the study and by Body Mass Index (BMI) testing on special equipment.  For me, I believe the aspects that contributed to weight loss were the intermittent fasting (no nighttime snacking), no sugar, high fat/low carb ketogenic diet which includes no bread. Exercise is also very important but I was doing that already. It was the food and fasting that were the new variables.

I’m Sleeping Better

  • Since I’ve been in this study my sleep has markedly improved.  I used to get up repeatedly to go to the bathroom and at times would have difficulty getting back to sleep. I now sleep through the night and when I do get up, I can fall right back asleep easily.
    From my understanding, the following that I’m taking positively affects my sleep. Remember it may look very different for you and your body.

Over the counter supplements:

    • NeuroMag by Designs for Health 3 capsules at bedtime  (=144 mg magnesium)
    • Melatonin SRT by Designs for Health 1 tablet bedtime (6mg)

Prescription meds

    • Progesterone 200mg cap (Costco has it the cheapest)
    • Naltrexone 3mg tablet

Improved Gum Health

  • Dentalcidin toothpaste with Biocidin by Bio-Botanical Research is the natural toothpaste that I’ve been provided to use for the entire clinical study. My dental hygienist asked me what I was doing differently as my gum health improved significantly. I told her about the study and apparently, the change in diet and toothpaste resulted in this improvement.  Marie, one of my Pilates students, started using this same toothpaste after my mentioning it and she shared this with me. “I went to my dentist yesterday and got a great review on how well my gums looked after using this natural toothpaste.”

Reflecting on this clinical trial I found further evidence of the efficacy of a multimodal approach to cognitive decline and the prevention of Alzheimer’s Disease.   Doctors often tell patients at high risk of Alzheimer’s due to having pre-dementia conditions—such as Mild Cognitive Impairment (MCI) or Subjective Cognitive Impairment (SCI)—that there is really nothing that they can do other than wait and monitor. A recent study from Australia suggests that advice may be out of date. Researchers found that modest lifestyle changes (e.g., a nutrition plan, a physical exercise plan, and BrainHQ brain training which was all included in my clinical trial plus more) significantly reduced Alzheimer’s risk after only eight weeks. You can read a news article about the study here.

As I contemplate life after ReCode, I know that I’ll continue brain training, sauna, intermittent fasting, and will continue with the Dentalcidin toothpaste. I’ll maintain aspects of the ketogenic diet, and will add some carb cycling in.  I miss things like my brown rice and beans, bananas, and sweet potatoes. I don’t really miss bread and will choose to keep that at bay. I believe dropping bread and sugar contributed to my weight loss.  As I prepare to have my final clinical study doctor appt on Oct. 8, I’ll be advised then on how to smoothly transition out of clinical study mode with guidelines on what supplements to continue and what I can drop.  I’ll fill you in on the details next month in my epilogue!

2nd Installment

Read 1st Installment Here.

Since the start of my ketogenic lifestyle journey on Dec 7th, 2019, I’ve lost 9 lbs and 2 1/2 inches off my waist. Though brain and metabolic health is my primary goal, this is a welcome byproduct and actually an expected result on a ketogenic diet.

I’m consistently in nutritional ketosis confirmed by daily prickings/blood readings. This was not easy at first as I don’t like needles or eliciting pain on myself.  With that said, the lancet is tiny and relatively painless and has become so easy now that I take multiple readings daily to monitor how my food is affecting my body.

The fact that I’m preferentially burning more fat for fuel and less glucose is good for brain health, decreasing inflammation and improving energy levels.  I feel strong, alert and am not experiencing the dips in energy I used to feel during the day from erratic blood sugar levels.  I don’t feel deprived or hungry at all. My sleep has improved dramatically which helps my body to heal and my brain to detoxify and regenerate.

An unexpected bonus, I just got back from the dentist and my hygienist was amazed at the improved status of my gums. She asked what I was doing differently and when I told her, she said the gum improvement was a direct result of the anti-inflammatory effects from the Keto diet.

Nuggets to Share with You

Intermittent fasting is something that helps boost your metabolism, healing, and weight loss.  We need to make sure we don’t eat for 3 hrs prior to going to bed. Our goal in the study is 12-16 hours of fasting each day. That may sound draconian at first but it’s really not that bad. If you have your last meal at 7 pm, you can eat 12 hrs later at 7 am the following morning. It also helps with sleep as your overactive digestive system won’t wake you up.

Sleep  Install f.lux (a free app) on your computer so that the blue lights will dim as the sun goes down. This helps your natural melatonin to do its job.  I started wearing a light-blocking eye mask ($10 for three on Amazon) at night to help with sleep and it’s helping tremendously. I had to get beyond the fact that they look like training bras for the eyes but the comfort and effectiveness won out! I’m going to try earplugs next.

Sauna is great for sweating out toxins. I’ve discovered through my lab work, that I have a high toxic load and because I don’t naturally sweat, even when I exercise at normal ambient temperatures. Because of that, I don’t detoxify well. I’ve now added with my doctor’s recommendation, 4 days of hot sweaty yoga and  1-2 days of dry sauna to accelerate the removal of my toxin burden.

I found the following quite interesting and pertinent to my goals.  A 2016 study done in Finland found that among those who used a sauna 4-7 times a week, the risk of any form of dementia was 66 percent lower and the risk of Alzheimer’s disease 65 percent lower than among those taking a sauna just once a week.

You can read more about the study Here

Online Brain Training is one of my daily requirements as a study participant. The program we are using, BrainHQ.com is the most scientifically validated program on the market. This is way beyond crossword puzzles in sophistication and the exercises get harder as you become more successful so it’s continually challenging your brain.  Check it out!  You can do it on your phone, iPad or laptop.

Favorite Keto Foods
Thankfully I love avocados and eat them daily with olive oil as they are a keto superfood. Packed with healthy fats, antioxidants, fiber, potassium, and magnesium, you can eat them on their own or put them in salads, smoothies or enjoy some guacamole.

Eggs have gotten a bad rap but they’re one of the most nutrient-dense foods on the planet – especially the yolk! I’ve been advised to only purchase ” Pasture Raised” eggs as they are the safest and healthiest.

My two new favorite snacks are macadamia nuts and raw cauliflower florets dipped in Trader Joe’s Mixed Nut Butter, a delicious blend of almonds, cashews, walnuts, brazil nuts, hazelnuts, and pecans.

In January we had a gathering of the clinical study participants with our doctor, nutrition coach and fitness coach. This allowed the participants to meet each other and share insights and challenges. The highlight of the meeting was a call in from Dr. Dale Bredesen, the creator of the protocol that we’re using. He was inspiring, answered all our questions with wisdom and humor and let us know through our participation in this study, that we were becoming a part of history.

Keto 101 Basics

If you’re interested in trying a ketogenic diet here are some of the main points.  You can also find plenty of info and recipes on the web.

Under normal circumstances, the cells of our body rely on glucose as their primary energy source. Glucose comes from dietary sources and from the breakdown of glycogen in the skeletal muscle and liver.  When glucose is in short supply, the cells tap into fats as an alternative source of fuel. The breakdown of fats leads to the production of ketone bodies and a metabolic state called ketosis.  The benefits of being in ketosis are listed at the end of this post.

Keto diet principles:

  • Fat: 60-75% of daily calories of daily calories
  • Protein: 20-35% of daily calories
  • Carbs: roughly 5% of daily calories

Most people are in chronic sugar burning mode due to a diet high in carbs for many years. That’s why it can take days to weeks on a low-carb, high-fat keto diet to get keto-adapted as the body learns to preferentially use fat/ketones for fuel.

What to Eat

Your diet should be a majority of healthy fats, polyunsaturated fats, and some saturated fats such as avocados, olive oil, coconut oil, fish oil, and ghee. This increases ketone bodies making the body crave fat instead of sugar.

Veggies preferred are non-starchy above-ground low carb veggies such as broccoli, cauliflower, zucchini, cabbages, and leafy greens. I’ve substituted spaghetti with zucchini noodles using my spiralizer and honestly don’t miss the pasta!

Onions, garlic, cilantro, and basil are all great additions.

 

Fruits: best are organic berries such as blackberries, blueberries, raspberries. strawberries, as well as lemons and grapefruit. Other fruit like bananas and oranges and tropical fruits like pineapples and mangoes are higher in carbs and should be avoided or minimized.

Alcohol is not recommended on this clinical study diet although red wine (1x /wk is permitted later in the study protocol)  Woo hoo!

We’re instructed to stay within 50 net carbs per day.  To calculate your Net carbs,  look at the label for Total Carbs and subtract Fiber and that = Net carbs.

For example: 1 serving of my Mixed Nut Butter is 7g carbs minus 3g of fiber so it’s 4grams total Net Carbs.

 

Are you afraid that eating fat will make you fat? 

That has been proven scientifically as incorrect. One of the major causes of fat accumulation is inflammation. Being in ketosis reduces inflammation and helps you lose extra fat weight as I’m experiencing first hand.

What to Buy

We’ve been advised to buy organic as much as possible with grass-fed meat and pasture-raised eggs to minimize toxic exposure of antibiotics and GMO’s. Grassfed animal products have the proper ratio of omega 6 to omega 3 to support optimal brain health, fat burning and keep inflammation levels down.  You’d be surprised how much affordable organic food you can find in Costco and Trader Joes.

Measuring Ketone Levels

There are several ways to measure your level of ketosis such as urine strips, breath monitors, and blood meters. The blood ketone reader  (I use Keto Mojo) is the gold standard, most precise and is what we’re using in the study. Here’s a link to the Keto Mojo kit on Amazon.  Although nutritional ketosis is defined as above 0.5 ml/mm, in the clinical study we’re shooting for a ketone level of 1.0 or above ml/mm as that level has been shown to better improve brain function and cognition.  Though it took me a while, I’m now pretty consistently at or above 1.0

Benefits of Ketosis as quoted by Dr. Jockers from DrJockers.com

  1. Reduced inflammation                                                 
  2. Enhanced mitochondrial health
  3. Reduced oxidative stress
  4. Increased mental clarity
  5. Abundant energy levels
  6. Reduced cravings
  7. Accelerated fat burning and Weight Loss
  8. Improved insulin sensitivity
  9. Reduced risk of chronic desease
  10. Improved mood and emotional balance
  11. Healthier Skin
  12. Anti-aging effects

Comment or post your questions below (rather than emailing me) to consolidate things and I’ll answer them as best I can and will try to include them in my next installment!

1st Installment

Do you find yourself forgetting appointments, names, where you put your keys, why you walked in that room you’re in? This is a concern for me.

My family history is steeped in Alzheimer’s Disease. It’s been difficult to witness my 94 y/o dad’s symptom progression. He is the last living sibling of a dozen brothers and sisters, more than half afflicted with this particular disease.

I’m certainly cognizant of my own risk especially as I begin to see my own decline in word recall, orientation, name/faces, etc.  But here’s the good news!

I just qualified to be in a national clinical study that’s administering a multi-modal approach to prevent or reverse cognitive decline. This approach was spearheaded already successfully by Dr. Dale Bredesen, author of the book “The End of Alzheimer’s: The First Program to Prevent and Reverse Cognitive Decline.”  This is a must-read if you have cognitive concerns. The link above takes you to the book on Amazon. I get no personal gain for recommending this. The science is cutting edge.

As a ReCode (Reversal of Cognitive Decline) clinical study participant, I’m required to be on a gluten-free, dairy-free, grain-free, alcohol-free, Ketogenic diet, am being closely monitored by a physician, have had a slew of genetic tests, MRI, blood, poo and pee tests and everything in between. I prick myself daily to check my ketone levels. I’m on bioidentical hormones. I’m also supported by a nutrition coach and fitness coach with specific fitness parameters. Daily I’m required to do brain building games on the computer, and a computer program that promotes mindfulness and stress reduction.

This is a 9-month study and though I miss my latte’s, rice and beans, chocolate and wine/cosmos,  I’m committed to the long haul and choose to focus not on what I’m giving up, but on what I stand to gain.

If any of you are well versed in Keto diets, ping me. I would love to acquire more knowledge and favorite recipes. I can use all the support I can get!

I anticipate learning tons on this journey and will assimilate key learnings into the classes I teach. I look forward to sharing with you here on this platform, any nuggets that might help you on your journey to physical and cognitive health.

Batch one of preorders ready to ship. More tomorrow.  
So excited and proud of this new BoneSmart Pilates Aging Strong Vol 2 DVD!  Two 25min full body workouts to fit into your busy schedule, a posture coaching segment and a bone building stomping easy to follow authentic Flamenco dance!
 
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